New York City is an epicenter of commerce, teeming with possibilities for budding entrepreneurs and established enterprises. If you’re in search of commercial buildings for rent, the platform Zillow provides an extensive array of options that cater to diverse business needs. Here’s a curated list of ten commercial properties available for rent across New York neighborhoods, alongside essential details to expedite your search.

As the city evolves, certain neighborhoods emerge as shining beacons for various types of businesses. Here’s a detailed look at where you can find promising commercial real estate on Zillow, ensuring you can navigate the bustling market efficiently.

1. 408 East 58th Street, Midtown East
A prime location for businesses seeking visibility, this building boasts over 5,000 square feet of flexible space, ideal for retail or office use. With its expansive windows offering ample natural light, the ambiance enhances productivity. Contact: (123) 456-7890. Website: Zillow.

2. 914 Broadway, Flatiron District
In the heart of the iconic Flatiron District, this loft-style commercial space is perfect for creative agencies and tech startups. With contemporary amenities, it affords both style and functionality. The historic vibe of the surroundings adds distinct charm. Contact: (234) 567-8901. Website: Zillow.

3. 55 West 39th Street, Garment District
Catering to fashion-forward enterprises, this building offers unique rental spaces designed for clothing retail. Located near major design firms, it positions you strategically within the fashion industry. Enjoy a lively atmosphere that invigorates work culture. Contact: (345) 678-9012. Website: Zillow.

4. 302 West 75th Street, Upper West Side
This charming brownstone has been converted into adaptable office space, featuring high ceilings and elegant woodwork. Ideal for small businesses or startups, it benefits from a residential vibe, attracting local clientele. Contact: (456) 789-0123. Website: Zillow.

5. 555 Hudson Street, West Village
This historical property offers a vast floor plan suited for restaurants or cafés. Located in the must-visit West Village, its inviting aesthetics are complemented by an intriguing history that could enhance your brand’s narrative. Contact: (567) 890-1234. Website: Zillow.

6. 124 Hudson Street, SoHo
Known for its artistic flair, this commercial space in SoHo perfectly fits galleries or boutique shops. The area receives ample foot traffic, further enriched by nearby art installations and fashion shops, ideal for attracting a vibrant clientele. Contact: (678) 901-2345. Website: Zillow.

7. 350 East 24th Street, Gramercy
A fantastic opportunity for medical professionals, this space includes a fully renovated waiting room and consultation areas. Its proximity to hospitals enhances its desirability for health-related businesses, ensuring a steady stream of clientele. Contact: (789) 012-3456. Website: Zillow.

8. 225 West 34th Street, Midtown
This towering building in Midtown is ideal for tech firms or large enterprises. Equipped with advanced facilities and a robust security system, it presents a professional aura conducive to corporate growth. Its central location near transport hubs ensures accessibility. Contact: (890) 123-4567. Website: Zillow.

9. 200 East 59th Street, Upper East Side
A charming penthouse-style office space that features natural light and panoramic views. This unique offering is attractive to firms seeking a prestigious business address while benefiting from the neighborhood’s upscale clientele. Contact: (901) 234-5678. Website: Zillow.

10. 211 West 148th Street, Harlem
This vibrant neighborhood is witnessing growth, making this retail space a savvy investment for businesses targeting a demographic shift. Embrace the rich culture and community, building connections with local consumers in an evolving marketplace. Contact: (012) 345-6789. Website: Zillow.

To navigate the maze of commercial listings effectively, employ strategic tactics. Utilize Zillow’s robust search filters to refine your options by price, size, or type of property. Moreover, familiarize yourself with the neighborhoods—each has distinct characteristics that could align with your business goals. Engaging a local real estate agent who specializes in commercial properties can also expedite the process, providing insights that online searches often lack.

As you embark on your search for the ideal commercial building for rent, consider the critical factors like lease terms, local demographics, and the potential for growth in the area. By leveraging online tools, local experts, and insightful community knowledge, you can find a space that not only meets your business requirements but also propels your entrepreneurial journey forward.

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Last Update: January 19, 2026